BMJ- The Ultimate Tissue Support

This is what Robert S. Hoffman, M.D. says about the BMJ:

“I take the BMJ formula myself, and I recommend it to my patients.”  

This is what people in the sports world say about BMJ.

Coach Harry Marra – National Director World’s Greatest Athlete Decathlon Club , USA :

“Training for the decathlon is a 7 day a week, year round regiment, spanning every aspect of physical development…Strength, speed, explosive power, aerobic endurance, coordination/skill acquisition, flexibility and mental training…It is inevitable that the body can not stand up to this type of daily grind without some parts becoming sore and inflamed. One injury and 4 years of training for the Olympic Games goes right down the drain. Since the late 1990’s, we have relied on the formula BMJ to assist our athletes in warding off these nagging aches and pains, especially in their joint areas, and I can without reservation say that formula BMJ has made a difference in our athletes preparation. Additionally, it has helped speed the recovery time from a demanding training session, so that the athletes were better prepared for their next practice. I have been involved in the sport of track and field and decathlon specifically since 1961…Everyone out there knows and understands my stance on performance enhancing supplements...I have been against them since day 1! Formula BMJ is a safe way to assist your body to feel better over the long run. I co ntinue to work out myself, and get those aches and pains like everyone else…Formula BMJ has helped me get back to the jogging paths more consistently. I recommend it fully.”

The BMJ formula provides support for the connective tissue in the body.

The Bone, Muscles, and Joint [a.k.a BMJ] is our most popular formula. This unique formula was designed to help support the tissue in your body which commonly causes problems as we get older. Radiological evidence of degenerative joint disease is found in more than 80% of people over the age of 55 and is the most common disease in humans ( Struss, J.K. et al., 1985 ) .

However, the BMJ formula is not just for the older population. There is a 35% incidence of osteoarthritis in the knees as early as age 30. When you think of how devastating and disabling knee pain can be it makes sense to do all you can to help prevent joint degeneration ( Bland, J.H., et al, 1984).

The following are some of the reasons why the BMJ is such an effective formula .

Glucosamine sulfate one of the ingredients in the BMJ formula has shown in two studies which were conducted over three years that cartilage degeneration stopped in the treatment group while the co ntrol group experienced further degeneration (Reginster J.Y. 2001, Pavelka, K. et al, 2002).

Numerous studies have shown glu co samine sulfate to be effective in decreasing osteoarthritic pain (Reginster J.Y. 2001, Pavelka, K. et al, 2002, Da Camara, C.C. et al, 1998, Foster, K.K., et al. 1995, Pujalte, J.M. et al, 1980, Drovanti, A., et al, 1980, D’Ambrosio, E., et al, 1981, Vaz, A.L., et al, 1982.).

The graph below shows research co mparing glu co samine sulfate with Ibuprofen for eight weeks (Vaz, A.L., 1982).

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After four weeks the glucosamine sulfate produced more pain relief than the Ibuprofen.

Research has documented that glucosamine sulfate supplies cartilage with building materials. Glucosamine sulfate caused a significant stimulation of proteoglycan production by chondrocytes (cartilage cells) in samples obtained from human osteoarthritic cartilage (Basleer C., et al, 1998). Another study showed that treatment of osteoarthritic chondrocytes with glucosamine sulfate resulted in an increased cell-mediated GAG (gly co saminoglycans) content (Dodge G.R., Jimenez S.A., 2003). GAG is a common building block both for cartilage, ligaments, and tendons.

Free radicals are also a factor involved in cartilage degeneration. Patients with osteoarthritis had approximately a four fold lower level of extra cellular SOD (superoxide dismutase), the body’s own antioxidant enzymes a co nstituent of cartilage (Regan E, Flannelly J, et al, 2005).

Zinc, copper, and manganese are necessary for the formation of SOD, that is one of the reasons these minerals are included in the BMJ.

A significant amount of vitamin D has been included. Here are some of the reasons why it is important. Osteoarthritis of the knee and hip progress more rapidly in patients with low levels of vitamin D (McAlindon T.E., et al, 1996, Lane N.E., et al, 1999). A high percentage of patients with non-traumatic persistent ,musculoskeletal pain have been found to be vitamin D deficient (Plotnikoff G.A., et al, 2003).

Many patients with low back pain were vitamin D deficient and supplementation with vitamin D led to pain reduction (Al Faraj S, et al, 2003).

We are using vitamin D3 (cholecalciferol) in the BMJ because vitamin D3 is much more efficient in raising and sustaining vitamin D levels (Vieth R, et al, 2001). Vitamin D2 potency is less than one third that of vitamin D3 and had much shorter duration of action co mpared to vitamin D3 (Armas L.A., et al, 2004). It is important to support healthy bone formation throughout life. Osteoporosis can be prevented in most cases if measures are taken earlier in life. It is also interesting that research indicates increased bone formation may protect against cartilage loss (Wang Y., et al, 2005). While calcium is one of the most important minerals we have, calcium by itself is not the best solution to help build strong and healthy bones.

We included a proper dose of a patented dicalcium malate, a very bioavailable source of calcium. See graph for comparison with one of the most common forms of calcium.

Excerpted and summarized from the full study entitled “Comparison of calcium Absorption from various calcium- containing products in Healthy Human Adults: A Bioavailability study”. Copyrights, Albion International, Inc. November, 2005

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Excerpted and summarized from the full study entitled “Comparison of calcium Absorption from various calcium- containing products in Healthy Human Adults: A Bioavailability study”. Copyrights, Albion International, Inc. November, 2005

When a two-year study compared perimenopausal women who took either 1000mg or 2000mg of calcium daily with a placebo group, a 3.2% loss of bone density in the spine was found in the placebo group, while the groups taking calcium increased bone density by 1.6%. No difference was found between the groups taking 1000mg or 2000mg indicating there is no reason to take high amounts ( Elders, P.J.M., et al, 1994).

The importance of vitamin D supplementation for bone formation has been verified in several studies. In one of these studies a group of older women taking 400 I.U. of vitamin D3 for two years showed a significant increase in bone density compared to the placebo group which instead showed decreased levels ( Ooms, M.E., et al. 1995) .

In a two year study of menopausal women, magnesium prevented fractures and resulted in a significant increase in bone density (Sojka J.E., Weaver C.M., 1995).

Magnesium increased bone density in postmenopausal women with osteoporosis documenting a significant difference compared to the control group (Stendig-Lindberg G., et al, 1993).

In young adult males magnesium supplementation caused a reduction in bone turnover suggesting beneficial effects in reducing bone loss associated with high bone turnover, such as age related osteoporosis (Dimai H.P., et al, 1998).

Bone density has been found to be significantly better when the minerals zinc, copper, manganese, and potassium was added to calcium when compared to only calcium (Strauss L., et al, 1994).

Dietary zinc intake and plasma zinc concentrations have been documented to be lower in men with osteoporosis, this has also been reported for women (Hyun T.H. et al, 2004).

Magnesium, in addition to its importance for bone formation, has been shown to help prevent kidney stones when taken with vitamin B6 (Prien E. et al, 1974, Gershoff S et al, 1967). We have also included vitamin B6 in the BMJ formula.

The minerals mangnesium, zinc, copper, and manganese are supplied as patented amino acid chelates for better bioavailability. As an example, when zinc bis-glycinate, the amino acid chelate used in the BMJ formula, was compared to zinc glu onate, the amino acid chelate zinc bis-glycinate had a 43.44% better bioavailability than the zinc gluconate (Gandia P., et al, 2007).

BMJ Formula

Only $45.95 for 240 Tablets

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References:

Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine. 2003;28(2):177-179.

Armas LA, et al. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91.

Bland, J.H., Cooper, S.M. Osteoarthritis: A review of the cell biology involved and evidence for reversibility. Management rationally related to known genesis and pathophysiology. Seminars in Arthritis and Rheumatism, 1984;Vol 14, No 2: 106-23.

Basleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glu co samine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage. 1998 Nov;6(6):427-34.

D’Ambrosio E, Casa B, Bompani R, et al. Glu co samine sulphate: a co ntrolled clinical investigation in arthrosis. Pharmatherapeutica 1981;2:504.

Da Camara, C.C., Dowless, G.V. Glu co seamine sulfate for osteoarthritis. Ann Pharma co ther, 1998; 32:580-87.

Dimai HP, et al. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.

Dodge GR, Jimenez SA. Glu co samine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage. 2003 Jun;11(6):424-32.

Dravanti, A., Bignamini, A.A., Rovati, A.L. Therapeutic activity of glu co seamine sulfate in osteoarthritis; a placebo co ntrolled double–blind investigation. Clin Ther, 1980; 3:260-72.

Elders, P.J.M., et al. Long term effect of calcium supplementation on bone loss in perimenopausal women. J Bone Min Res, 1994; 9:963-70.

Foster-Powell K, Miller JB. International tables of glycemic index. Am J Clin Nutr, 1995;62:871-93.

Gandia, P. et al. A bioavailability study co mparing two oral formulations co ntaining Zinc after a single administration to twelve healthy female volunteers. Int.J.Vitmn.nutr res., 77 (4) 2007, 243-248.

Gershoff S, Prien E., Effect of Daily MgO and Vitamin B6 Administration to Patients with Recurring Calcium Oxalate Stones. Am J. Clin. Nutr., 20, 1967: 393-399.

Hyun TH, et al. Zinc intakes and plasma co ncentrations in men with osteoporosis: the Rancho Bernardo Study. Am J Clin Nutr. 2004 Sep;80(3):715-21.

Lane NE, Gore LR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Arthritis Rheum. 1999;42(5):854-860.

McAlindon TE, Felson DT, et al. Relationship of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. 1996;125(5):353-359.

Ooms, M.E., et al. Prevention of bone loss with vitamin D supplement in elderly women: a randomized double–blind study. J Clin Endocrinal Metabol, 1995; 80:21052-58.

Pavelka, K., Gatterova, J., et al. Glu co seamine sulfate use and delay of progression of knee osteoarthritis. A 3-year, randomized, placebo- co ntrolled, double-blind study. Arch Intern Med, 2002; 162:2113-23.

Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78(12):1463-1470.

Prien E., Gershoff S., Magnesium Oxide-Pyridoxine Therapy for recurrent Calcium Oxalate Calculi. J. Urol. 1974:112:509-512.

Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral Glu co samine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980; 7:110.

Regan E, Flannelly J, et al. Extracellular superoxide dismutase and oxidant damage in osteoarthritis. Arthritis Rheum. 2005 Nov;52(11):3479-91.

Reginster JY, et al. Long-term effects of glu co seamine sulfate on osteoarthritis progression: a randomized, placebo- co ntrolled clinical trial. Lancet.,2001:357:251-256.

Sojka JE, Weaver CM. Magnesium supplementation and osteoporosis. Nutr Rev. 1995 Mar;53(3):71-4.

Stendig-Lindberg G, et al. Trabecular bone density in a two year co ntrolled trial of peroral magnesium in osteoporosis. Magnes Res. 1993 Jun;6(2):155-63.

Struss, J.K. et al. Evaluation of an educational program for primary care practitioners on the management of osteoarthritis. Arthritis and Rheumatism, 1985;Vol 28, No 1.

Strauss L, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr. 1994 Jul;124(7):1060-4.

Vaz AL. Double-blind clinical evaluation of the relative efficacy of ibuprofen and Glu co samine sulphate in the management of osteoarthrosis of the knee in outpatients. Curr Med Res Opin 1982;8:145.

Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001;73(2):288-294.

Wang Y, Ebeling PR, Hana F, et al. Relationship between bone markers and knee cartilage volume in healthy men. J Rheumatol. 2005 Nov;32(11):2200-4.