|Where Recommendations are Based on Scientific Evidence|
Nutr Metab Cardiovasc Dis. 2009 Mar 18. [Epub ahead of print]
Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population.
Laboratory of Genetic and Environmental Epidemiology. Research Laboratories, "John Paul II" Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Largo Gemelli 1, 86100 Campobasso, Italy.
BACKGROUND AND AIMS: Dietary habits have been associated with cardiovascular disease (CVD) risk factors. This study aimed at evaluating the association of non-predefined dietary patterns with CVD risk profile and C-reactive protein (CRP). METHODS AND RESULTS: We analyzed 7646 healthy subjects from the Moli-sani project, an on-going cross-sectional cohort study of men and women aged >/=35, randomly recruited from a general Italian population. The Italian EPIC food frequency questionnaire was used. Food patterns were generated using principal factor analysis (PFA) and reduced rank regression (RRR). Three dietary patterns were identified by PFA. The "Olive Oil and Vegetables" pattern, characterized by high intake of olive oil, vegetables, legumes, soups, fruits and fish, was associated with relatively lower values of glu cose, lipids, CRP, blood pressure and individual global CVD risk s core. The "Pasta and Meat" pattern, characterized by high intake of pasta, tomato sauce, red meat, animal fats and al cohol, was positively associated with glu cose, lipids, CRP and CVD risk s core. The "Eggs and Sweets" pattern, characterized by positive loadings of eggs, processed meat, margarines, butter, sugar and sweets, was associated with high values of CRP. The first RRR pattern was similar to the "Pasta and Meat" pattern both in composition and association with CVD risk profile. CONCLUSIONS: In a large healthy Italian population, non-predefined dietary patterns including foods considered to be rather unhealthy, were associated with higher levels of cardiovascular risk factors, CRP and individual global CVD risk, whereas a "prudent-healthy" pattern was associated with lower levels.
PMID: 19303267 [PubMed - as supplied by publisher]
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