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Mult Scler. 2008 Jul 24.
Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis.
Smolders J, Menheere P, Kessels A, Damoiseaux J, Hupperts R.
School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; Department of Internal Medicine, division of Clinical and Experimental Immunology, University Hospital Maastricht, Maastricht, The Netherlands.
BackgroundMultiple Sclerosis is associated with low serum levels of 25-hydroxyvitamin D (25(OH)D). We investigated the association between serum levels of 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active metabolite, and clinical MS severity as expressed by EDSS-score and relapse rate.Study-designCross-sectional study.Patients and MethodsSerum samples from 267 MS patients were collected for 25(OH)D and 1,25(OH)2D measurement. Clinical MS parameters at the date of serum sampling were determined. Results: Both metabolite levels were significantly lower in the progressive forms compared to the relapsing remitting (RR)MS phenotype. In RRMS patients (disease course Serum levels of 25(OH)D were associated with both relapse rate and disability in MS patients. These results are suggestive for a disease modulating effect of the serum concentrations of 25(OH)D on MS. The low circulating 1,25(OH)2D levels in progressive MS are due to older age and lower 25(OH)D levels. The potential consequences for vitamin D supplementation in MS will be discussed.
PMID: 18653736 [PubMed - as supplied by publisher]
PMID: 18653736 [PubMed - as supplied by publisher]